Острые лейкозы Причины

Делитесь на здоровье
Острые лейкозы остаются распространенными заболеваниями среди всех опухолевых заболеваний крови. В последние годы наблюдается тенденция к увеличению случаев заболеваний ОЛ В мире, в общем, И В России И по Красноярскому краю в частности, а также наблюдается рост числа госпитализаций по данному поводу.

В большинстве случаев конкретная причина возникновения острых лейкозов остается неизвестной. Однако существуют предрасполагающие факторы, которые значительно увеличивают риск развития этих заболеваний. На первом месте, можно выделить врожденные И приобретенные хромосомные аномалии. Роль вирусов в развитии лейкозов доказана в отношении РНК- ретровирусов.

Четко доказана взаимосвязь между ионизирующей радиацией при взрыве атомной бомбы, а также химио- И радиотерапией по поводу других опухолей с повышенным риском возникновения острых лейкозов. Доказано, что между курением И риском развития острого лейкоза существует дозовая зависимость, которая особенно наблюдается у лиц старше 60 лет. Длительное воздействие ряда химических средств также повышает риск возникновения острого лейкоза.

Таким образом, хромосомные аномалии, вирусы, ионизирующая ра- диация, химио- и радиотерапии, курение, химические вещества И наследственный фактор могут способствовать появлению того или иного гемобластоза, увеличивая риск возникновения заболевания, однако до конца неизвестна точная первопричина заболевания. В основе возникновения острого лейкоза лежит мутация клоногенной кроветворной клетки с последующими событиями, приводящими к нарушениям пролиферации, дифференцировки И апоптоза клеток с накоплением патологического продукта.

В настоящее время полностью не изучены патогенетические механизмы, вызывающие нарушение нормальной функции клетки и запускающие патологические процессы, в конечном итоге, приводящие к возникновению лейкозов. Еще одним фактором, обусловливающим развитие онкологического заболевания, является снижение реактивности иммунной системы.

С одной стороны доказано, что именно иммунодефицитное состояние определяет развитие злокачественной опухоли. С другой стороны, накапливается все больше сведений, что и сама опухоль индуцирует развитие иммунной супрессии, которая может проявляться в широком диапазоне (от незначительной степени до полной анергии). Механизмы, ответственные за нарушения функции иммунной системы, в настоящее время полностью не определены.

В целом, установлено, что у больных онкологическими заболеваниями дисфункция иммунной системы проявляется в нарушении функции антигенпрезентирующих клеток, эффекторной функции Т-лимфоцитов, уменьшении пролиферативного индекса. И экспрессии отдельных субъединиц рецептора интерлейкина-2, а также в нарушении баланса синтеза цитокинов. Несмотря на ряд проведенных исследований, многое в патогенезе острого лейкоза остается неизученным.

Недостаточно полно исследованы механизмы иммунной реактивности при остром лейкозе. Полностью отсутствуют исследования метаболического статуса клеток иммунной системы при данных заболеваниях. В то же время известно, что интенсивность метаболических процессов в значительной степени определяет функцию клеток иммунной системы.

При этом наибольшей информативностью при исследовании метаболизма лимфоцитов обладают окислительно-восстановительные ферменты, так как они осуществляют ключевые реакции клеточного метаболизма И координируют сопряженные метаболические пути. Не Исследованными остаются особенности иммунного статуса, состояние метаболизма лимфоцитов. В зависимости от вида лейкоза И стадии заболевания.

Просмотров: 116

71 комментарий для “Острые лейкозы Причины

  1. Howdy would you mind sharing which blog platform you’re working with?
    I’m planning to start my own blog in the near
    future but I’m having a tough time deciding between BlogEngine/Wordpress/B2evolution and
    Drupal. The reason I ask is because your layout seems different then most blogs and
    I’m looking for something completely unique.
    P.S My apologies for getting off-topic but I had to ask!

    P.S. If you have a minute, would love your feedback on my new
    website
    re-design. You can find it by searching for «royal cbd» —
    no sweat if you can’t.

    Keep up the good work!

  2. great post, very informative. I wonder why the opposite specialists
    of this sector do not understand this. You should proceed
    your writing. I am confident, you have a huge readers’ base already!

  3. Hmm is anyone else encountering problems with the pictures
    on this blog loading? I’m trying to figure out
    if its a problem on my end or if it’s the blog. Any suggestions would be greatly appreciated.

  4. Thanks for the marvelous posting! I certainly enjoyed reading it, you
    will be a great author.I will ensure that I bookmark your blog and will eventually come back
    sometime soon. I want to encourage you to definitely continue your great posts,
    have a nice afternoon!

  5. Hi to all, how is everything, I think every one is getting more
    from this site, and your views are pleasant for new viewers.

  6. Pretty portion of content. I just stumbled upon your web site and in accession capital to assert that
    I acquire in fact enjoyed account your weblog posts. Any way I will be subscribing on your augment and even I success you get right of entry to persistently quickly.

  7. Amazing things here. I am very satisfied to peer your post.
    Thanks so much and I’m having a look forward to touch you.
    Will you kindly drop me a e-mail?

  8. Can I simply just say what a comfort to find a person that genuinely understands what
    they are talking about online. You definitely understand how
    to bring an issue to light and make it important.
    More people must read this and understand this side of your story.
    I was surprised that you are not more popular since you definitely have the gift.

  9. I am extremely impressed with your writing skills
    and also with the layout on your blog. Is this a
    paid theme or did you modify it yourself? Either way keep up the nice quality writing,
    it’s rare to see a great blog like this one nowadays.

  10. What’s up, its good piece of writing about media print, we all be familiar with media is a wonderful source of information.

  11. I feel that is one of the so much vital info for me. And i’m happy reading
    your article. But wanna remark on few common things, The site taste is ideal, the articles is really great : D.
    Good process, cheers

  12. I’m truly enjoying the design and layout of your blog.
    It’s a very easy on the eyes which makes it much more enjoyable for me to come here and visit more often. Did you hire out a designer to create your theme?
    Outstanding work!

  13. Good post. I learn something new and challenging on sites I stumbleupon everyday.
    It’s always interesting to read content from other authors and
    practice something from other web sites.

  14. Do you have a spam problem on this website;
    I also am a blogger, and I was wanting to know your situation; many of us have created some nice practices and we are looking to
    trade solutions with other folks, be sure to shoot me
    an email if interested.

  15. No matter if some one searches for his required thing, so he/she wants
    to be available that in detail, therefore that
    thing is maintained over here.

  16. Hi! I’ve been reading your website for a long time now and finally got the courage to go ahead and
    give you a shout out from New Caney Tx! Just wanted to
    say keep up the excellent work!

  17. I’m really enjoying the theme/design of your weblog. Do you ever run into any browser compatibility problems?
    A couple of my blog audience have complained about my site not working correctly in Explorer but looks great in Safari.
    Do you have any recommendations to help fix this issue?

  18. When I initially commented I clicked the “Notify me when new comments are added”
    checkbox and now each time a comment is added I get three emails with the same comment.
    Is there any way you can remove me from that service?
    Appreciate it!

  19. I am regular visitor, how are you everybody?
    This paragraph posted at this web page is actually pleasant.

  20. We’re a group of volunteers and starting a new scheme in our community.
    Your website provided us with useful information to work on. You have done a formidable job and our whole community will likely
    be grateful to you.

  21. Fantastic website. A lot of useful info here.
    I’m sending it to a few pals ans additionally sharing in delicious.
    And of course, thanks in your effort!

  22. It is perfect time to make some plans for the longer
    term and it is time to be happy. I have learn this submit and if I may just I desire
    to recommend you some fascinating issues or advice.
    Maybe you could write subsequent articles relating
    to this article. I want to learn even more things about it!

  23. Hi! I could have sworn I’ve been to this website before but after looking
    at many of the articles I realized it’s new to me.
    Nonetheless, I’m certainly pleased I stumbled upon it and I’ll be bookmarking it and checking back regularly!

  24. Way cool! Some very valid points! I appreciate you writing this article
    plus the rest of the website is also very good.

  25. It’s remarkable to pay a quick visit this web site and reading the views of
    all colleagues concerning this paragraph, while I am also
    eager of getting experience.

  26. Really when someone doesn’t know then its up to other visitors that they will help,
    so here it takes place.

  27. What’s Taking place i’m new to this, I stumbled
    upon this I’ve found It positively useful and
    it has helped me out loads. I’m hoping to give a contribution & aid different users like its aided me.

    Good job.

  28. Hi there, I think your blog could be having browser compatibility problems.

    When I take a look at your site in Safari, it looks
    fine however, if opening in IE, it has some overlapping issues.
    I merely wanted to provide you with a quick heads up!

    Other than that, wonderful blog!

  29. I am really loving the theme/design of your website.
    Do you ever run into any web browser compatibility issues?
    A few of my blog visitors have complained about my site not operating correctly in Explorer but looks great in Firefox.
    Do you have any suggestions to help fix this problem?

  30. I’m not that much of a internet reader to be honest but
    your sites really nice, keep it up! I’ll go ahead and bookmark
    your site to come back down the road. Cheers

  31. I’m impressed, I have to admit. Rarely do I come across a blog that’s equally educative and amusing,
    and without a doubt, you have hit the nail on the head.
    The problem is something which too few people are speaking intelligently about.

    Now i’m very happy that I found this in my search for something
    concerning this.

  32. Wonderful beat ! I would like to apprentice while you amend your website, how can i subscribe for a weblog web site?
    The account helped me a applicable deal. I had been tiny
    bit acquainted of this your broadcast offered bright clear concept

  33. Hi! I simply wish to give you a huge thumbs up for the excellent info you’ve got
    here on this post. I’ll be coming back to your site for more soon.

  34. Hey! I could have sworn I’ve been to this site before but after browsing through some of the post I realized it’s new to me.
    Anyhow, I’m definitely glad I found it and I’ll be book-marking and checking back often!

  35. Heya i am for the first time here. I came across this board
    and I find It really useful & it helped me out much. I hope to give something back and help others like you helped me.

  36. I have learn some good stuff here. Certainly price bookmarking for revisiting.
    I surprise how a lot effort you set to create this type
    of magnificent informative website.

  37. Hi there! I know this is kinda off topic but I’d
    figured I’d ask. Would you be interested in exchanging links or maybe guest writing a blog post or vice-versa?
    My site goes over a lot of the same topics as yours and I feel we
    could greatly benefit from each other. If you might be interested
    feel free to shoot me an e-mail. I look forward to hearing from you!
    Fantastic blog by the way!

  38. If some one wants expert view about blogging and site-building then i advise him/her
    to go to see this webpage, Keep up the good work.

  39. Hi, i believe that i saw you visited my site so i came to return the prefer?.I
    am attempting to in finding things to improve my web site!I assume
    its adequate to make use of some of your ideas!!

  40. Very nice post. I just stumbled upon your weblog and wanted
    to say that I have truly enjoyed surfing around your blog posts.
    After all I’ll be subscribing to your rss feed and I hope you write
    again soon!

  41. Everything is very open with a clear description of the issues.
    It was really informative. Your site is extremely helpful.
    Thank you for sharing!

  42. I pay a visit day-to-day some blogs and information sites to read articles
    or reviews, however this webpage provides quality based content.

  43. Simply desire to say your article is as surprising. The clearness in your post is just excellent and i could assume you are an expert on this subject.
    Well with your permission allow me to grab your RSS feed to
    keep updated with forthcoming post. Thanks a million and
    please continue the rewarding work.

  44. Appreciation to my father who stated to me on the topic of
    this website, this weblog is really amazing.

  45. What’s up, I desire to subscribe for this blog to obtain latest updates, therefore where can i
    do it please help out.

  46. Pretty nice post. I just stumbled upon your weblog and
    wanted to say that I have truly enjoyed browsing your blog posts.
    After all I will be subscribing to your rss feed and I hope you write again soon!

  47. This piece of writing presents clear idea in favor of the new viewers
    of blogging, that truly how to do blogging and site-building.

  48. I precisely wanted to thank you very much again. I do not know what I would’ve used without the ideas revealed by you on such a area. This was the hard problem in my opinion, nevertheless taking a look at your specialised fashion you treated that made me to jump over contentment. I’m just grateful for this information and in addition hope you find out what a great job you have been undertaking teaching the rest by way of your web blog. Most probably you have never encountered any of us.

  49. Hi! Someone in my Facebook group shared this site with us so I came to give it a look.
    I’m definitely enjoying the information. I’m bookmarking and will be tweeting this to
    my followers! Superb blog and excellent design and style.

  50. Thanks a lot for providing individuals with an extraordinarily nice chance to read from this website. It can be so excellent and packed with a great time for me and my office acquaintances to visit your web site not less than 3 times per week to read the fresh issues you have. Not to mention, we’re at all times fulfilled for the special pointers served by you. Certain 4 facts in this post are indeed the most suitable we have had.

  51. I’m really enjoying the theme/design of your site.
    Do you ever run into any web browser compatibility issues?
    A number of my blog readers have complained about my website not operating correctly in Explorer but looks great in Chrome.

    Do you have any tips to help fix this issue?

  52. I used to be more than happy to find this internet-site.I wanted to thanks to your time for this wonderful read!! I undoubtedly having fun with each little little bit of it and I have you bookmarked to check out new stuff you weblog post.

  53. I constantly emailed this blog post page to all my friends,
    since if like to read it then my links will too.

  54. I do consider all the ideas you’ve presented in your post.
    They’re very convincing and will certainly work. Nonetheless, the posts are too quick
    for starters. May you please prolong them a little from next time?
    Thanks for the post.

  55. Wonderful post however I was wondering if you could write a
    litte more on this topic? I’d be very grateful
    if you could elaborate a little bit further.
    Thank you!

  56. I was more than happy to search out this internet-site.I wanted to thanks to your time for this excellent read!! I positively having fun with each little bit of it and I’ve you bookmarked to take a look at new stuff you weblog post.

  57. An fascinating dialogue is worth comment. I believe that you must write extra on this topic, it might not be a taboo topic but usually individuals are not enough to talk on such topics. To the next. Cheers

  58. This web page is known as a walk-through for all the data you wanted about this and didn抰 know who to ask. Glimpse right here, and you抣l undoubtedly uncover it.

  59. Wow, this piece of writing is pleasant, my younger sister
    is analyzing such things, so I am going to convey her.

  60. I used to be more than happy to find this internet-site.I needed to thanks for your time for this excellent read!! I definitely having fun with every little bit of it and I have you bookmarked to check out new stuff you weblog post.

  61. I discovered your weblog web site on google and examine just a few of your early posts. Proceed to maintain up the excellent operate. I simply additional up your RSS feed to my MSN News Reader. Searching for forward to reading extra from you afterward!?

Добавить комментарий

Ваш адрес email не будет опубликован. Обязательные поля помечены *

Translate »